Catalyst recycling via hydrogen-bonding-based affinity tags.

نویسندگان

  • Bas W T Gruijters
  • Maarten A C Broeren
  • Floris L van Delft
  • Rint P Sijbesma
  • Pedro H H Hermkens
  • Floris P J T Rutjes
چکیده

[Structure: see text] A novel procedure for catalyst recycling is described. Copper(I)-based catalysts, equipped with an affinity tag, are isolated from crude reaction mixtures on the basis of quadruple hydrogen-bonding interactions using a resin functionalized with complementary affinity tags. Recycled catalysts were successfully used to catalyze a tandem Sonogashira coupling/5-endo-dig cyclization and a Cu-catalyzed [3+2] Huisgen cycloaddition reaction in high yields.

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عنوان ژورنال:
  • Organic letters

دوره 8 15  شماره 

صفحات  -

تاریخ انتشار 2006